Introduction of Han Hu

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Han Hu joined the Innovation Team of Honeybee Proteomics as an Assistant Professor in 2015.The major research focus is honeybee cellular biology and proteomics.She is now working on the cultivation of honeybee cell line and investigation of the mechanism of protein biosynthesis of the secretion of royal jelly in hypopharyngeal gland of worker bees.she has publishe 5 papers as the first author in the SCI-included joumals.

Email: huhan@caas.cn

Research Interests

In recent years, the group’s innovative research programs address the honey bee proteomics, and form our prominent advantage and obvious characteristics. I focus on the honey bee biological behavior, especial the royal jelly secretion. Through in-depth study of produce pulp biology of royal jelly, we have partially revealed the mechanism of the high production of royal jelly. However, the biological functions of key genes and proteins of hypopharyneal gland (HG), the main royal jelly produce organ, are not clear. Towards the goal of elucidating the molecular underpinnings of increased activity in the HGs of nurse bees, DNA methylatome, transcriptome and proteome were used to compare the genetic evolution and transcriptional regulation of the HGs in nurse bees.


09/2007 - 06/2010  Ph.D. Animal  Nutrition, Gansu Agricultural University

09/2001 - 06/2004  Master, Biomedical Polymer Materials, Wuhan University

09/1997 - 06/2001  Bachelor, Polymer Materials and Engineering, Wuhan Institute of Technology

Work Experience

2017/11-2018/5, Visiting scholar, Institute of Biotechnology, Cornell University

2015/03-Until now, Assistant researcher, Beekeeping Lab., Institute of Apicultural Science, Chinese Academy of Agricultural Sciences

2010/08-2014/08, Postdoctor, Ruminant nutrition Lab., Institute of Animal Science, Chinese Academy of Agricultural Sciences

2006/07-2007/10, Research Assistant, Ruminant nutrition Lab., Institute of Animal Science, Chinese Academy of Agricultural Sciences

2005/06-2006/05, Technician, Proteomics facility, National Institute Biological Sciences

2004/10-2005/06, Technician, Protein and peptide drug Lab., Institute of Biophysics Chinese Academy Sciences


First Author

1.      Han Hu, Kaspar Bienefeld, Jakob Wegener, et al., Proteome Analysis of the Hemolymph, Mushroom Body, and Antenna Provides Novel Insight into Honeybee Resistance against Varroa Infestation. J. Proteome Res. 2016, 15, 2841−2854.

2.      Han Hu, Nan Zheng, Haina Gao, et al., Immortalized bovine mammary epithelial cells express stem cell markers and differentiate in vitro. Cell Biology International, 2016, 40:861–872.

3.      Han Hu, Nan Zheng, Jianbo Cheng, et al. The Effect of Heat Stress on Gene Expression and Synthesis of Heat-shock and Milk Proteins in Bovine Mammary Epithelial Cells. Animal Science Journal, 2015, 87(1): 84-91.

4.      Han Hu, Jiaqi Wang, Haina Gao, et al. Heat-induced Apoptosis and Gene Expression in Bovine Mammary Epithelial Cells. Animal Production Science, 2015, 56(5): 918-926.

5.      H. Hu, N. Zheng, J. Q. Wang, er al. Immortalization of a Primary Bovine Mammary Epithelial Cell Line by the SV40 large T-antigen gene. J. Anim. Sci., 2014, 90, Suppl. 3/J. Dairy Sci., 2014, 95, Suppl. 2.

6.      H. Hu, J. Q. Wang, D. P. Bu, et al. Heat-induced stress and response of bovine mammary epithelial cells.. J. Anim. Sci., 2013, 90, Suppl. 3/J. Dairy Sci., 2013, 95, Suppl. 2.

7.      Han Hu, Jiaqi Wang, Dengpan Bu, et al. Modification of protein synthesis of bovine mammary epithelial cells induced by heat shock. J. Anim. Sci., 2012, 90, Suppl. 3/J. Dairy Sci., 2012, 95, Suppl. 2.

8.       Han HuJiaqi Wang, Dengpan Bu, et al.In vitro culture and characterization of a mammary epithelial cell line from Chinese Holstein dairy cow. PLoS One2009.01.014 (11)e7636~e7636.


1.       Pei Fan, Bin Han, Mao Feng, Yu Fang, Lan Zhang, Han Hu, et al. Functional and Proteomic Investigations Reveal Roles of Major Royal Jelly Protein 1 in Anti-hyptertension in Mouse Vascular Smooth Muscle Cell. Scientific Report. 2016; 6: 30230.

2.      Xinmei Huo, Bin Wu, Mao Feng, Bin Han, Yu Fang, Yue Hao, Lifeng Meng, Abebe Jenberie Wubie, Pei Fan, Han Hu, Yuping Qi, and Jianke Li. Proteomic Analysis Reveals the Molecular Underpinnings of Mandibular Gland Development and Lipid Metabolism in Two Lines of Honeybees (Apis mellifera ligustica). J. Proteome Res. 2016, 15, 3342−3357.

3.       Mao FengYu FangBin HanXiang XuPei FanYue HaoYuping QiHan Hu, et al. In-Depth N-Glycosylation Reveals Species-Specific Modifications and Functions of the Royal Jelly Protein from Western (Apis mellifera) and Eastern Honeybees (Apis cerana). J. Proteome Res., 2015, 14 (12): 5327-5340.

4.       Yu FangMao FengBin HanYuping QiHan Hu, et al. Proteome Analysis Unravels Mechanism Underling the Embryogenesis of the Honeybee Drone and Its Divergence with the Worker (Apis mellifera lingustica). J. Proteome Res., 2015, 14 (9): 4059-4071.

5.       Bin HanYu FangMao FengHan Hu, et al. Quantitative Neuropeptidome Analysis Reveals Neuropeptides Are Correlated with Social Behavior Regulation of the Honeybee Workers. J. Proteome Res., 2015, 14 (10): 4382-4393.

6.      Hai-na Gao, Nan Zheng, Jia-qi Wang, Han Hu, et al. Leucine and histidine independently regulate milk protein synthesis in bovine mammary epithelial cells via mTOR signaling pathway. J Zhejiang Univ Sci B2015.6.0116(6)560~572.

7.      Xuemei Nan, Dengpan Bu, Xiyan Li, Jiaqi Wang, Hongyang Wei, Han Hu, et al. Ratio of Lysine to Methionine alters expression of genes involved in milk protein transcription and translation and mTOR phosphorylation in bovine mammary cells, Physiological Genomics, 2014, Apr 1;46(7):268-75.

8.       Liu X, Wang W, Hu H, Tang N, Zhang C, Liang W, and Wang M. Smad3 specific inhibitor, naringenin, decreases the expression of extracellular matrix induced by TGF-β1 in cultured rat hepatic stellate cells. Pharmaceutical Research. 2006; 23(1): 82-89.

9.       Liu XJ, Hu H and Yin JQ. Therapeutic strategies against TGF-β signaling pathway in Hepatic Fibrosis. Liver International. 2005, 25: 1-25.

10.   Zhi-Lan Liu, Han Hu, and Ren-Xi Zhuo, Konjac Glucomannan-graft- Acrylic Acid Hydrogels Containing Azo Crosslinker for Colon-Specific Delivery. Journal of Polymer Science: Part A: Polymer Chemistry2004, 42(17): 4370-7378.

Last update: December 5, 2017

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